SP-2577 and Analogs
Proceedings of the National Academy of Sciences
LSD1 activates a lethal prostate cancer gene network independently of its demethylase functionJournal of medicinal chemistry
High-throughput virtual screening identifies novel N′-(1-phenylethylidene)-benzohydrazides as potent, specific, and reversible LSD1 inhibitors.Blood
Clinical Efficacy of Combined Therapy with LSD1 Antagonist SP-2509 and Pan-Histone Deacetylase Inhibitor Against AML Blast Progenitor Cells.AACR
Inhibition of LSD1 disrupts global EWS/ETS transcriptional function in Ewing sarcoma.Prostate cancer and prostatic diseases
Reversible lysine-specific demethylase 1 antagonist HCI-2509 inhibits growth and decreases c-MYC in castration-and docetaxel-resistant prostate cancer cells.
LSD1’s Role in Cancer