Publications

Proceedings of the National Academy of Sciences

LSD1 activates a lethal prostate cancer gene network independently of its demethylase function

Journal of medicinal chemistry

High-throughput virtual screening identifies novel N′-(1-phenylethylidene)-benzohydrazides as potent, specific, and reversible LSD1 inhibitors.

Blood

Clinical Efficacy of Combined Therapy with LSD1 Antagonist SP-2509 and Pan-Histone Deacetylase Inhibitor Against AML Blast Progenitor Cells.

AACR

Inhibition of LSD1 disrupts global EWS/ETS transcriptional function in Ewing sarcoma.

Cell

LSD1 Ablation Stimulates Anti-tumor Immunity and Enables Checkpoint Blockade

ACS chemical biology

Lysine-specific histone demethylase 1 inhibitors control breast cancer proliferation in ERα-dependent and-independent manners.

Cancer cell

Androgen receptor gene expression in prostate cancer is directly suppressed by the androgen receptor through recruitment of lysine-specific demethylase

Biochemical Journal

GFI1 functions in transcriptional control and cell fate determination require SNAG domain methylation to recruit LSD1